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This also means that there are variations in musicality across the different pieces, and interesting patterns can emerge.įor example, music generated from the receptor protein that binds to the hormone and neurotransmitter oxytocin has some recurring motifs due to the repetition of certain small sequences of amino acids. Because the algorithm was completely based on the amino acid sequence and no two proteins share the same amino acid sequence, each protein will produce a distinct song. The resulting music is complex, with notable variations in pitch, loudness, and rhythm. A larger-sized amino acid, for instance, would have a shorter note length, and vice versa. Each amino acid in the protein is mapped to a particular note based on how frequently they appear in the protein, and other aspects of their biochemistry correspond with other aspects of the music. To test the algorithm, we applied it to 18 proteins that play a key role in various biological functions. In this case, we chose to analyze features of Chopin’s Fantaisie-Impromptu to guide our development of the program. These features allowed us to test out a greater range of notes in our protein-to-music mapping algorithm. Songs are usually homophonic, meaning they follow a central melody with accompaniment. Music from this period also tends to have lighter and more graceful and emotive melodies.
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This enhances musicality, or the melodiousness of the song, when converting amino acid properties, such as sequence patterns and variations, into analogous musical properties, like pitch, note lengths, and chords.įor our study, we specifically selected 19th-century Romantic period classical piano music, which includes composers like Chopin and Schubert, as a guide because it typically spans a wide range of notes with more complex features such as chromaticism, like playing both white and black keys on a piano in order of pitch, and chords. Protein-to-music mapping can be fine-tuned by basing it on the features of a specific music style. Enhancing the Musicality of Protein Mapping Protein-to-music algorithms can thus map the structural and physiochemical features of a string of amino acids onto the musical features of a string of notes. Likewise, music consists of sound waves of higher and lower pitches, with changing tempos and repeating motifs. Protein chains can also fold into wavy and curved patterns with ups, downs, turns, and loops. A protein chain can be represented as a string of these alphabetic letters, very much like a string of music notes in alphabetical notation. These chains are composed of small units of 20 possible amino acids, each labeled by a letter of the alphabet. Proteins are structured like folded chains.
#Chopinistic as in chopin music how to
So we led a team of high school students and other scholars to figure out how to create classical music from proteins. While creating music based on proteins isn’t new, different musical styles and composition algorithms had yet to be explored. We’re computational biologists who believe that hearing the sound of life at the molecular level could help inspire people to learn more about biology and the computational sciences. These analogies can be used not only to help advance research, but also to make the complexity of proteins accessible to the public. There are many surprising analogies between proteins, the basic building blocks of life, and musical notation. With the right computer program, proteins become pleasant music.